Integrated Bioinformation and Specimen Center

The National Jewish Health Integrated Bioinformation and Specimen Center represents an ongoing, institutionally-sponsored effort to collect and store the data, tissue, fluids and DNA on thousands of our patients who have generously agreed to participate in this program.

Leveraging the clinical phenotyping by our physicians, our internally developed research database, a pathology image database and our biorepository, we can offer our investigators and partners highly characterized information and corresponding samples for research in the full gamut of respiratory and immunologic disease. It is our hope that this unique resource will aid in the discovery of genetic tests and biomarkers that may be useful in predicting who may get a disease, the likely course of the disease and how it may be most effectively treated.

 

Research Database

The Biostatistics and Bioinformatics Division has developed and maintains the Research Database, which provides access to data on over 85,000 patients and research subjects in a single, searchable repository.  Its phenotypic data includes allergy history, demographics, diagnoses, medications, lab tests, imaging reports, and vital signs/findings. These data are further integrated with clinical research databases and the institutional biorepository data.

 

Biorepository

Approved researchers can use the Research Database to view clinical data and find biorepository samples in a completely de-identified way to aid in the initial formulation of a research study. Following IRB approval and a simple application to the research database advisory committee, detailed clinical data and the corresponding biologic samples will be made available to the approved investigator.

Currently archived biologic materials include:

-80ºC

• Serum 400µl or 800µl
• Plasma - EDTA 400µl or 800µl
• Plasma - Heparin 400µl or 800µl
• Buffy coat - EDTA 100µl
• Buffy coat - Heparin 100µl
• BAL - Supernatant 1.8 ml

-145ºC  

• Serum 400µl or 800µl  
• Plasma - EDTA 400µl or 800µl  
• Plasma - Heparin 400µl or 800µl  
• Buffy coat - EDTA 100µl 
• Buffy coat - Heparin 100µl 
• BAL-cells 1.8 ml
• RBCs - EDTA 1 ml
• Blood/DMSO 1 ml
• Lung tissue - Fresh Frozen (0.5-1 cm3) 

Other

• DNA, formalin-fixed tissue

 

Contacts

Steve D. Groshong, MD Principal Investigator George Halley Administrator John Yang Research Coordinator

Ted D. Wade, PhD Principal Investigator, Research Database Rick Hum Research Database Project Coordinator Pearlanne Zelarney Research Data Curator