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Photograph of Philippa Marrack FRS

Philippa Marrack FRS, PhD

Specialties: Allergy, Asthma, Autoimmunity/Rheumatology, Basic Immunology, Cellular and Molecular Biology
Main Phone: 303-398-1322
Fax: 303-270-2166
Department(s): Integrated Department of Immunology

Education

Cambridge University, England, PhD, 1970
Cambridge University, England, BA, MA, 1967

Fellowships

University of California, San Diego, Postdoctoral fellowship with Dr. Richard Dutton, 1971-1973

Interests

Immunology Research

We study T cells. T cells are amongst the cells which recognize that an infection is occurring in the body. They accomplish this in an unexpected way, by reacting with fragments of the infection bound to special proteins of the body, the MHC proteins. We are trying to find out how T cells learn to react in this way. We are also interested in the ways in which T cells are prevented from attacking MHC proteins bound to fragments of their own host. In most people such attack is efficiently avoided. However, in some individuals T cells do react in this way, and this event causes autoimmune diseases such as rheumatoid arthritis and juvenile diabetes. On the other side of the coin, the vaccines work by stimulating the ability of T cells to attack invaders. We study how vaccines accomplish this, with the hope that this understanding will help us design better vaccines.

Patients/Research

Conducts research.

Affiliation with University of Colorado Health Sciences Center

Distinguished Professor of the University of Colorado

Professor in the Integrated Dept. of Immunology and the Depts. of Biochemistry and Molecular Biology and Medicine

Honors, Awards, Chairs, or Professional Activities

2004:National Jewish Medical and Research Center Abraham J. Kauvar Presidential Award
2004: University of Colorado Health Sciences Center, School of Medicine, Mentoring Award
2004: L’Oreal UNESCO for Women in Science Award
2003: Faculty Ambassador Award, National Jewish Medical and Research Center
2000: Lifetime Achievemant Award, American Association of Immunologists
2001: Irvington Institute Scientific Leadership Award in Immunology
1999: Interscience Conference on Antimicrobial Agents and Chemotherapy Award
1999: University of Chicago, Howard Taylor Ricketts Prize
1998: The Rabbi Shai Schacknai Memorial Prize
1996: Honorary Doctorate of Sciences, Macalester College
1995: Dickson Prize in Medicine, University of Pittsburgh
1995: Behring-Heidelberger Lecture Award
1995: FASEB Excellence in Science Award
1995: The Louisa Gross Horwitz Prize-Columbia University
1993: The Paul Ehrlich and Ludwig Darmstädter Prize, Germany
1993: Cancer Research Institute''s 1993 William B. Coley Award for Distinguished Research in Fundamental Immunology
1992: The Ernst W. Bertner Memorial Award, MD Anderson Cancer Center
1991: Honorary Doctorate of Sciences, University of Rochester

Professional Memberships/Societies

British Society of Immunology
American Association of Immunologists
The Royal Society
The National Academy of Sciences USA
American Academy of Arts and Sciences

Recent or Important Publications

Jordan*, M., Mills*, D.M., Kappler, J., Marrack^, P. and .Cambier^, J.C. Alum administration primes B cell MHC class II/Iga/b signal transduction in vivo by induction of a novel, IL-4-producing, Gr1+ myeloid cell population. Science 304: 1808-1810, 2004.

Huseby, E.S., Crawford, F., White, J., Kappler, J. and Marrack, P. Negative selection imparts peptide specificity to the mature T cell repertoire. Proc. Natl. Acad. Sci. USA, 100:11565-70, 2003.

Hildeman, D., Zhu, Y., Mitchell, T.C., Bouillet, P., Strasser, A., Kappler, J. and Marrack, P. Activated T cell death in vivo mediated by proapoptotic Bcl-2 family member Bim. Immunity 16: 75-767, 2002.

Mitchell, T.C., Hildeman, D., Kedl, R.M., Teague, T.K., Schaefer, B.C., White, J., Zhu, Y., Kappler, J. and Marrack, P. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nature Immunol. 2: 397-402, 2001.

Ku, C.C.*, Murakami, M.*, Sakamoto, A., Kappler, J. and Marrack, P. Homeostasis of CD8+ memory T cells is controlled by opposing cytokines. Science 288:675-678, 2000.

^^These authors contributed equally to the work.

Curriculum Vitae

You can view this physician's curriculum vitae online.

© Copyright 2007 National Jewish Medical and Research Center

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